After transitioning to PI in 2019

* Corresponding author


41. Yang M, Hutchinson N, Yin J, Guan M, Wang Z, Chen P, Yang S, Crane JD, Zhang K, He X, Li J*. Engineered Bacillus subtilis as oral probiotics to target circulating lactic acid. bioRxiv 2023.12.01. doi:

40. Nam H, Xie K, Majumdar I, Yang S, Starzyk J, Lee D, Shan R, Li J*, Wu H*. TESOGENASE, An Engineered Nuclease Editor for Enhanced Targeted Genome Integration. bioRxiv 2023.08.28.553855; doi: under revision in Nature Communications

39. Zhang L, Du H, Sun X, Cheng F, Lee W, Li J, Dai G, Fang N, Liu Y. 3D Printing of Interpenetrating Network Flexible Hydrogels with Enhancement of Adhesiveness. ACS Applied Materials & Interfaces, 2023.

38. Shi X, Sadeghi P, Lobandi N, Emam S, Abrishami S, Martos-Repath I, Mani S, Nasrollahpour M, Sun W, Rones S, Kwok J, Shah H, Charles J, Khan Z, Pagsuyoin S, Rojjanapinun A, Liu P, Chae J, Costa M, Li J, Sun X, Yang M, Li J, Dy J, Wang J, Luban J, Chang W, Finberg R, Urbashi Mitra, Cash S, Robbins G, Hodys C, Lu H, Wiegand P, Rieger R, Sun X, Novel, accurate pathogen sensors for fast detection of SARS-CoV-2 in the aerosol in seconds for a breathalyzer platform, Biosensors and Bioelectronics: X, Volume 14, 2023, 100369, ISSN 2590-1370,

37. Yang M#, Dong PT#, Cen L, Shi W, He X*, Li J*. Targeting Fusobacterium nucleatum through Chemical Modifications of Host-Derived Transfer RNA Fragments. The ISME Journal, 2023. (# co-first) PDF

Selected as Editor’s Choice, a selection of key papers from each issue that highlight some of the best research published in The ISME Journal

Also refer to a news report


36. Al-Dossary A.A., Isichei A.C., Zhang S, Li J, Errachid A, Elaissari A. Outer Membrane Vesicles (OMVs) as a Platform for Vaccination and Targeted Drug Delivery. Pharmaceutical Nanobiotechnology for Targeted Therapy. Nanotechnology in the Life Sciences. Springer. 2022.

35. Wong W, Crane ED, Hui Zhang, Li J, Day TA, Green AE, Menzies KJ, Crane JD. Pgc-1α controls epidermal stem cell fate and skin repair by sustaining NAD+ homeostasis during aging. Molecular Metabolism, 2022. PDF

34. He Y, Hong C, Fletcher SJ, Berger AG, Sun XYang M, Huang S, Belcher AM, Irvine DJ, Li J, Hammond PT. Peptide-based Cancer Vaccine Delivery via the STINGΔTM-cGAMP Complex. Adv. Healthcare Mater, 2022, 2200905.

33. Chen P, Wang D, Wang Y, Zhang L, Wang Q, Liu L, Li J, Sun X, Ren M, Wang R, Fang Y, Zhao JJ, Zhang K. Maximizing TLR9 Activation in Cancer Immunotherapy with Dual-Adjuvanted Spherical Nucleic Acids. Nano Letters, 2022.

32. Sun X, Yang S, Al-Dossary AA, Broitman S, Ni Y, Guan M, Yang M, Li J*. Nanobody-Functionalized Cellulose for Capturing SARS-CoV-2. Applied and Environmental Microbiology, 2022 Mar 8;88(5): e0230321. PDF See a comment article from


31. Sun X, Ni Y, He Y, Yang M, Tani T, Kitajima S, Barbie DA, Li J*. Engineering the Immune Adaptor Protein STING as a Functional Carrier. Advanced Therapeutics, 2021. PDF Selected as the Cover Picture in the Special Issue:Next Generation Immunotherapies

30. Al-Dossary AA, Tawfik EA, Isichei AC, Sun X, Li J, Alshehri AA, Alomari M, Almughem FA, Aldossary AM, Sabit H, Almalik AM. Engineered EV-Mimetic Nanoparticles as Therapeutic Delivery Vehicles for High-Grade Serous Ovarian Cancer. Cancers, 2021; 13(12):3075. PDF

29. Sun X, Hay I, Doran P, Basireddy S, Scott M, Wu Y, Al-Dossary AA, Li J*. Chapter Thirteen – Delivery strategies for STING agonists. Systemic Drug Delivery StrategiesVolume 2 of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy, 2021. Pages 333- 357.

28. Hapach LA, Carey SP, Schwager SC, Taufalele PV, Wang W, Mosier JA, Ortiz-Otero N, McArdle TJ, Goldblatt ZE, Lampi MC, Bordeleau F, Marshall JR, Richardson IM, Li J, King MR, Reinhart-King CA. Phenotypic heterogeneity and metastasis of breast cancer cells. Cancer Research, 2021 Jul 1;81(13):3649-3663.

27. He Y, Hong C, Irvine DJ, Li J*, Hammond PT*. In vitro STING Activation with the cGAMP-STINGΔTM Signaling Complex. Bio-protocol, 2021.

26. Zhao H, Li T, Gu Z, Liu C, Li J, Yang D. Intralysosomal environment-responsive metal-organic framework for microRNA delivery and synergetic gene/chemodynamic therapy of triple-negative breast cancer. ACS Applied Materials & Interfaces, 2021.


25. Zhang X, Al-Dossary A, Hussain M, Setlow P, Li J*. Applications of Bacillus subtilis Spores in Biotechnology and Advanced Materials. Applied and Environmental Microbiology, 2020 Aug 18;86(17): e01096-20. PDF

24. He Y, Hong C, Yan Z.E, Li Y, Zhu G, Yang M, Li Y, Sun X, Irvine DJ, Li J*, Hammond PT*. Self-Assembled cGAMP-STINGΔTM Signaling Complex as a Bioinspired Platform for cGAMP Delivery. Science Advances, 2020 Jun 12;6(24):7589. PDF

23. Yang M, Zhu G, George K, Sun X, Setlow P, Li J*. Engineering Bacillus subtilis as a Versatile and Stable Platform for Production of Nanobodies. Applied and Environmental Microbiology, 2020 Apr 1;86(8). PDF See a comment article from Dr. Daniel Zeigler, the former director of Bacillus Genetics Stock Center

Before transitioning to PI in 2019

22. Mensah L, Morton SW, Li J, Xiao H, Quadir MA, Elias KM , Penn E, Richson AK , Ghoroghchian PP, Liu J, Hammond PT.  Layer-by-Layer Nanoparticles for Novel Delivery of Cisplatin and PARP Inhibitors for Platinum-Based Drug Resistance Therapy in Ovarian Cancer. Bioengineering Translational Medicine, 2019 Jun 14;4(2): e10131.

21. Ludwicki MB#, Li J#, Stephens EA, Roberts RW, Koide S, Hammond PT, and DeLisa MP. Broad-spectrum proteome editing with an engineered bacterial ubiquitin ligase mimic. ACS Central Science, 2019 May 22;5(5):852-866. (# co-first)

20. Choi KY, Correa S, Min J, Li J, Roy, S, Laccetti KH, Dreaden EC; Kong S, Roun, H, Roh, YH, Lawson, EC, Palmer, PA, Hammond PT, Binary Targeting of siRNA to Hematologic Cancer Cells In Vivo using Layer-by-Layer Nanoparticles. Advanced Functional Materials, 2019 May 16;29(20):1900018.

19. Wu C, Li J, Wang W, Hammond PT. Rationally Designed Polycationic Carriers for Potent Polymeric siRNA-Mediated Gene Silencing. ACS Nano, 2018 Jul 24;12(7):6504-6514.

18. He Y, Hong C, Li J, Howard MT, Li Y, Turvey ME, Uppu DSSM, Martin JR, Zhang K, Irvine DJ, Hammond PT. Synthetic Charge-Invertible Polymer for Rapid and Complete Implantation of Layer-by-Layer Microneedle Drug Films for Enhanced Transdermal Vaccination. ACS Nano, 2018 Oct 23;12(10):10272-10280.

17. Bu P, Chen KY, Xiang K, Johnson C, Crown SB, Rakhilin N, Ai Y, Wang L, Xi R, Astapova I, Han Y, Li J, Barth BB, Lu M, Gao Z, Mines R, Zhang L, Herman M, Hsu D, Zhang GF, Shen X. Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. Cell Metabolism, 2018 Apr 18. pii: S1550-4131(18)30244-4.

16. Li J, Wu C, Wang W, He Y, Elkayam E, Joshua-Tor L, Hammond PT. Structurally Modulated CoDelivery of siRNA and Argonaute 2 for Enhanced RNA Interference. Proceedings of the National Academy of Sciences, 2018 Mar 20;115(12).

15. Zanotelli MR, Goldblatt ZE, Miller JP, Bordeleau F, Li J, VanderBurgh JA, King MR, Reinhart-King CA. Regulation of ATP utilization during metastatic cell migration by collagen architecture. Molecular Biology of The Cell, 2018 Jan 1;29(1):1-9.

14. He Y, Li J, He HK, Irvine DJ, Hammond PT. Synthetic Lift-off Polymer beneath Layer-by-layer Films for Surface Mediated Drug Delivery. ACS Macro Letters, 2017, 6 (11), pp 1320–1324.

13. Li J, He Y, Wang W, Wu C, Hong C, Hammond PT. Polyamine-Mediated Stoichiometric Assembly of Ribonucleoproteins for Enhanced mRNA Delivery. Angewandte Chemie International Edition, 2017 Oct 23;56(44):13709-13712. (Selected as a “Very Important Paper” designated to less than 5% of all articles published in the journal; MIT homepage spotlight on Sep 20, 2017, Highlighted by ChemistryViews).

12. Li J, Wang W, He Y, Li Y, Yan E, Irvine DJ, Hammond PT. Structurally programmed assembly of translation initiation nanoplex for superior mRNA delivery. ACS Nano, 2017 Mar 28;11(3):2531-2544. (Highlighted by ACS Nano)

11. Chandrasekaran S, Chan MF, Li J, King MR. Super natural killer cells that target metastases in the tumor draining lymph nodes. Biomaterials, 2016 Jan;77:66-76.

10. Li J, Sharkey CC, Liesveld J, King MR. Genetic engineering of platelets to neutralize circulating tumor cells. Journal of Controlled Release, 2016 Apr 28;228:38-47.

9. Sharkey CC, Li J, Roy S, Wu Q, King MR. Two-stage nanoparticle delivery of piperlongumine and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) anti-cancer therapy. Technology, 2016 Feb.

8. Li J, Ai Y, Wang L, Bu P, Sharkey CC, Wu Q, Wun B, Roy S, Shen X, King MR. Platelet membrane-functionalized particles to target tumor cell-associated micro-thrombi. Biomaterials, 2016 Jan;76:52-65. (Highlighed by C&EN News)

7. Li J, Sharkey C, King MR. Piperlongumine and immune cytokine TRAIL synergize to promote tumor death. Scientific Reports, 2015;5:9987.

6. Li J, Sharkey CC, Huang D, King MR. Nanobiotechnology for the Therapeutic Targeting of Cancer Cells in Blood. Cellular and Molecular Bioengineering, 2015:1-14.

5. Geng Y, Chandrasekaran S, Agastin S, Li J, King MR. Dynamic Switch Between Two Adhesion Phenotypes in Colorectal Cancer Cells. Cellular and Molecular Bioengineering, 2014;7:35-44.

4. Li J, Guillebon AD, Hsu JW, Barthel SR, Dimitroff CJ, Lee YF, King MR. Human fucosyltransferase 6 enables prostate cancer metastasis to bone. British Journal of Cancer, 2013;109:3014-22.

3. Bu P, Chen KY, Chen JH, Wang L, Walters J, Shin YJ, Goerger JP, Sun J, Witherspoon M, Rakhilin N, Li J, Yang H, Milsom J, Lee S, Zipfel W, Jin MM, Gümüş ZH, Lipkin SM, Shen X. A microRNA miR34a-regulated bimodal switch targets notch in colon cancer stem cells. Cell Stem Cell, 2013;12:602-15.

2. Li J, Bu P., Chen K. and Shen X. Spatial perturbation with synthetic protein scaffold reveals robustness of asymmetric cell division. Journal of Biomedical Science and Engineering, 2013, 6, 134-143.

1. Li J, King MR. Adhesion receptors as therapeutic targets for circulating tumor cells. Front Oncology, 2012;2:79.